Hepatic Dose : No dose adjustment recommended. Dose as in normal renal functionĭialysed. Renal Dose : Dose in Renal Impairment GFR (mL/min)ĭose in Patients undergoing Renal Replacement Therapies No significant interactions are known other than antagonism of coumarin anticoagulants. A role in bone metabolism, as well as in the renal reabsorption of Ca++. Neonates: In infants (particularly premature babies), excessive doses of vitamin K analogs during the first few days of life may cause hyperbilirubinemia this in turn may result in severe hemolytic anemia, hemoglobinuria, kernicterus, leading to brain damage or even death. Used as an antidote in poisoning by dicoumarol or warfarin. Large doses of vitamin K or its analogues may further depress liver function in patients with severe hepatic disease and thereby further decrease the concentration of prothrombin. Vitamin K1, also known as Phytonadione, is used in the treatment of warfarin overdose or toxicity. Pain, swelling, and tenderness at the injection site may occur. Bronchospasm, shock, cardiac and/or respiratory arrest may also occur. Transient flushing sensations and peculiar sensations of taste have been observed following phytonadione injection as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea, and cyanosis. The action of this class of anticoagulants may be reversed by administering vitamin K for the duration of the anticoagulants residence in the body. Alternatively, 10 mg IV, IM or subcutaneously may be administered.
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